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KMID : 0370220170610030171
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Yakhak Hoeji
2017 Volume.61 No. 3 p.171 ~ p.177
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Effects of Licochalcone E Derivatives on the Production of Inflammatory Mediators Induced by LPS
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Cho Young-Chang
Yoon Goo
Cheon Seung-Hoon
Kang Bok-Yun
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Abstract
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Licochalcone E is a retrochalcone isolated from the roots of Glycyrrhiza inflate. We previously reported that licochalcone E inhibited IL-12p40 production and attenuated chronic allergic contact dermatitis (ACD). Among the derivatives of licochalcone E, compound #74 ((E)-3-(5-Bromo-4-hydroxy-2-methoxyphenyl)-1-(4-ethoxyphenyl)prop-2-en-1-one) inhibited the production of IL-12p40, TNF-α, and IL-6, and NF-κB signaling pathway from LPS stimulated RAW264.7 macrophages. The effect of compound #74 (0.5, 1, and 5%) on ACD model was very weak
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KEYWORD
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Licochalcone E derivatives, Macrophage, Inflammation, Cytokines
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